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Brand name: qualaquin
Generic name: Quinate, Circonyl, Quinarsal, Q200, Quinbisu, Aethylcarbonis Chinin, Genin, Quinine-Odan, Quininga, Novo-Quinine, Kinin, Quinsul, Quinimax, Qualaquin, Q300, Apo-Quinine, quinine

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Although tetracycline may be concomitantly administered with Qualaquin, patients should be monitored closely for adverse reactions associated with quinine sulfate. Adjustment of Qualaquin dosage is not necessary when isoniazid is given concomitantly. Therefore the concomitant administration of rifampin with Qualaquin should be avoided (See WARNINGS). Qualaquin should be discontinued in case of any signs or symptoms of hypersensitivity (See CONTRAINDICATIONS). Carbamazepine, phenobarbital, and phenytoin are CYP3A4 inducers and may decrease quinine plasma concentrations if used concurrently with Qualaquin. Computer assisted modeling and simulation indicates that in patients with malaria and severe chronic renal failure, a dosage regimen consisting of one loading dose of 648 mg Qualaquin followed 12 hours later by a maintenance dosing regimen of 324 mg every 12 hours will provide adequate systemic exposure to quinine (See DOSAGE AND ADMINISTRATION). Qualaquin is also contraindicated in patients with known hypersensitivity to mefloquine or quinidine because cross-sensitivity to quinine has been documented (See PRECAUTIONS). 0 hours, but the mean Cmax and AUC0-24h were similar to those achieved when Qualaquin capsule was given under fasted conditions (See DOSAGE AND ADMINISTRATION). Patients taking medications that are CYP2D6 substrates with Qualaquin should be monitored closely for adverse reactions associated with these medications. Patients using Qualaquin for any other use should have their therapy discontinued. Do not take quinine (Qualaquin) or quinidine (used to treat malaria or irregular heart beat) with Lariam. Therefore, concomitant administration of troleandomycin with Qualaquin should be avoided (See WARNINGS). Thus, clinicians considering combined therapy of Qualaquin with atorvastatin or other HMG-CoA reductase inhibitors ("statins") that are CYP3A4 substrates (e. Qualaquin should be stopped immediately upon the appearance of evidence of hemolysis (See CONTRAINDICATIONS). Although no change in the Qualaquin dosage regimen is necessary with concomitant ketoconazole, patients should be monitored closely for adverse reactions associated with quinine. When a single oral 324 mg capsule of Qualaquin was administered to healthy volunteers (N=26) with a standardized high-fat breakfast, the mean Tmax of quinine was prolonged to about 4. Despite these pharmacokinetic changes, an alteration in the Qualaquin dosage regimen in elderly patients is not needed. Plasma theophylline concentrations should be monitored frequently during concurrent therapy with theophylline or aminophylline and Qualaquin. Patients being treated for malaria should have risk/benefit re-evaluated in order to continue treatment with Qualaquin. Therefore, concurrent use of Qualaquin with these medications, or drugs with similar properties, should be avoided (See PRECAUTIONS/Drug Interactions). The concomitant administration of mefloquine and Qualaquin may produce electrocardiographic abnormalities (including QTc prolongation) and may increase the risk of seizures (See WARNINGS). Although cimetidine may be used concomitantly with Qualaquin, patients should be monitored closely for adverse events associated with quinine. If Qualaquin is used concomitantly with any of these statins, lower starting and maintenance doses of the statin should be considered. Concurrent use of Qualaquin and mefloquine may also increase the risk of seizures (See PRECAUTIONS/Drug Interactions). Thus, if Qualaquin is administered to patients receiving digoxin, plasma digoxin concentrations should be closely monitored, and the digoxin dose adjusted, as necessary (See PRECAUTIONS).

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